Endocrine Abstracts

Introduction: Meigs’ syndrome is defined as the presence of a benign ovarian tumour (fibroma), in association with ascites and hydrothorax. The characteristic feature of this condition is the resolution of the effusions once the tumour is surgically removed.Case report: A 63 year-old female patient was admitted to the Surgery Clinic with metroragia, abdominal distention, and a recent history of minor breath shortness. Pulmonary clinical examination ...

Proton nuclear magnetic resonance spectroscopy (1H-NMR) was applied to investigate metabolic profile of type 2 diabetes mellitus (T2DM) patients and identify possible disorders of T2DM.We investigate the potential relationship between diabetic retinopathy (DR), diabetic neuropathy (DN), estimated glomerular filtration rate (eGFR), anthropometric indicators (body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), waist to sta...

Introduction: Adrenal myelolipoma is a rare benign tumour composed of mature adipose tissue and haematopoietic elements developed within the adrenal gland, usually unilateral, asymptomatic, and non-functional. Their real incidence is unknown.Case report: A 56 year-old female was admitted to our surgery department for abdominal distension and the presence of a large palpable tumour in the right abdomen discovered during an abdominal ultrasonographic check...

Seventy percent of women bearing PCOS are obese; adiponectin and TNFα, as obesity markers, have a dual role in the sensitivity and action of insulin. Adiponectin (insulin sensitising) decreases, whereas, TNFα, IL6 (negative regulators of insulin pathway) increases in obese-women. Moreover, TNFα decreases the transcript and protein levels of adiponectin. These changes could affect the normal energetic status in endometrium, tissue that exhibits abnormal insulin s...

Introduction: Generously supported by IPSEN)-->Carbohydrate metabolism (CHM) is impaired in over 30% of acromegalic patients. Natural history of acromegaly and treatment modalities, i.e. surgery, somatostatin analogues (SSA) and pegvisomant, may impact in a different way on CHM.Aim: To assess CHM alterations (impaired fasting glucose (IFG) and diabetes mellitus (DM)) in acromegaly and their relationship with cl...

Chronically elevated GH levels in GH-transgenic mice derive in accelerated growth and increased body weight. These animals present increased circulating IGF-I and hepatic IGF-I mRNA levels, as well as liver enlargement due to hypertrophy and hyperplasia, which frequently progress to hepatomas as the animals age.We have previously described that the GH-induced JAK2/STAT5 signalling pathway is desensitized in the liver of transgenic mice overexpressing GH....

Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant inherited disease with a high degree of penetrance. The three most common locations of tumors are the parathyroid glands, the gastro-duodenum pancreas and/or the anterior pituitary gland. The gene involved in this disease is MEN 1, a tumor suppressor gene located on chromosome 11q13. The objective of our work was to describe the genotype of patients with MEN 1 born in Argentina.Subjects ...

Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represent a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We have previously determined that fat accumulation reduces SHBG production in different non-alcoholic fatty liver disease (NAFLD) mouse models and that SHBG plays an active role in the development of this disease. In the present work, we are interes...

Abstract: Congenital hypogonadotropic hypogonadism (CHH) is characterized by isolated GnRH deficiency in the absence of central anatomical causes. Classically considered to be a permanent disorder, CHH reversal has been reported in up to 15% of cases. However, reversal may not always be life-long, as hypogonadism relapse can occur in a subset of patients. Criteria for reversal normalization of circulating sex steroids, and spontaneous fertility. We report a 26-yrs-old man, who...

Introduction: It is known that about 75% of cases of endogenous Cushing síndorme to a pituitary adenoma (HA) ACTH-producing, 15% to ectopic ACTH and 10% is due to adrenal adenoma.Case: The patient was 64 years old, derived from Diabetes Mellitus type 2 of about 16 years of history with an unwieldy+hypertension diagnosed in 2007 with no physical signs compatible with hypercortisolism and incidentally detected a left adrenal adenoma 2 cm. Hormonal blo...